Estimation of Alzheimer's disease dementia through a multi-state model

 
   Lead Investigator:    Javier Sanchez Alvarez
   Institution      :    F. Hoffmann-La Roche AG
   E-Mail           :    javier.sanchez_alvarez@roche.com
   Proposal ID      :    1482



   Proposal Description:
   The goals and objectives are:     1- To re-estimate the transition probabilities shown in papers like Green         Zhang (2016) fitting a multi-state Markov model rather than a simple fixed        cohort approach.                                                                  2- To understand the uncertainty around the transition probabilities estimated.   3- To analyze what is the best way to aggregate/disaggregate these transition     probabilities, as well as the use of alternative covariates to estimate the       states.                                                                           4- To use different methods to impute the missing data in Green  Zhang (2016),    which cover around 10 of patients.                                                5- To update the data with more recent estimates, as the original dataset used    in the paper is from 2014.